Histone deacetylase inhibitors

Details Histone deacetylase inhibitors Histone deacetylase inhibitors

A - Human Necessities

61

K

A61K 31/19 (2006.01) C07C 259/04 (2006.01)

Patent

CA 2574035

This invention relates to iminodiacetic acid and diamine hydroxamic acid derivatives, that are inhibitors of histone deacetylase (HDAC), and are useful in the prevention and/or treatment of cellular proliferative diseases, for example cancer, autoimmune, allergic and inflammatory diseases, diseases of the central nervous system (CNS) such as neurodegenerative diseases, and in the prevention and/or treatment of restenosis.

L'invention porte sur des dérivés de l'acide iminodiacétique et de l'acide diamine hydroxamique, inhibiteurs de l'histone déacétylase (HDAC), et utilisables pour la prévention et/ou le traitement de maladies à prolifération cellulaire dont le cancer, et les maladies auto-immunes, allergiques ou inflammatoires, les troubles du SNC dont les maladies neurodégénératives, et pour la prévention et/ou le traitement des resténoses.

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