Histone deacetylase inhibitors

Details Histone deacetylase inhibitors Histone deacetylase inhibitors

C - Chemistry, Metallurgy

07

C

C07C 259/06 (2006.01) C07C 235/84 (2006.01) C07C 259/10 (2006.01)

Patent

CA 2703231

Novel compounds of the general formula (I), having histone deacetylase (HDAC) inhibiting enzymatic activity, their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, intermediates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites and prodrugs thereof. The present invention more particularly provides novel compounds of the general formula (I). Also included is a method for treatment of cancer, psoriasis, proliferative conditions and conditions mediated by HDAC, in a mammal comprising administering an effective amount of a novel compound of formula (I).

L'invention concerne de nouveaux composés de formule générale (I), qui présentent une activité enzymatique d'inhibition de l'histone désacétylase (HDAC), leurs dérivés, analogues, formes tautomères, stéréoisomères, polymorphes, hydrates, solvates, intermédiaires, sels pharmaceutiquement acceptables, compositions pharmaceutiques, métabolites et promédicaments. La présente invention concerne plus particulièrement de nouveaux composés de formule générale (I). L'invention concerne également un procédé de traitement du cancer, du psoriasis, des troubles prolifératifs et des troubles induits par HDAC, chez un mammifère, qui comprend l'administration d'une quantité efficace d'un nouveau composé de formule (I).

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