Histone deacetylase inhibitors

Details Histone deacetylase inhibitors Histone deacetylase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 235/18 (2006.01) A61K 31/4184 (2006.01)

Patent

CA 2518318

Compounds that may be used to inhibit histone deacetylase having the formula (I) or formula (II) wherein M is a substituent capable of complexing with a deacetylase catalytic site and/or a metal ion; L is a substituent providing between 0-10 atoms separation between the M substituent and the remainder of the compound; and Z and Q are as defined herein.

La présente invention a trait à des composés utilisés pour l'inhibition d'histone déacétylase de formule Z- Q - L - M (I) ou de formule Z - L - M (II), dans lesquelles : M est un substituant capable de former un complexe avec un site catalytique de déacétylase et/ou un ion métallique, L est un susbtituant assurant une séparation entre 0 et 10 atomes entre le substituant M et le reste du composé ; et Z et Q sont tels que définis dans la description.

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