C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 295/088 (2006.01) A61K 31/27 (2006.01) A61K 31/40 (2006.01) A61K 31/44 (2006.01) A61K 31/5375 (2006.01) C07C 271/22 (2006.01) C07D 213/30 (2006.01)
Patent
CA 2576959
This invention relates to hydroxamic acid derivatives having a carbamate linkage, that are inhibitors of histone deacetylase (HDAC), and are useful in the prevention and/or treatment of cellular proliferative diseases, for example cancer, autoimmune, allergic and inflammatory diseases, diseases of the central nervous system (CNS) such as neurodegenerative diseases, and in the prevention and/or treatment of restenosis.
L'invention concerne des dérivés d'acide hydroxamique présentant une liaison carbamate, lesquels sont des inhibiteurs de l'histone déacétylase (HDAC), et sont utilisés dans la prévention et/ou le traitement de maladies prolifératives cellulaires, par exemple, cancer, maladies auto-immunes, allergiques et inflammatoires, maladies du système nerveux central (CNS), telles que maladies neurodégénératives, ainsi que dans la prévention et/ou le traitement de la resténose.
Belvedere Sandro
Hamblett Christopher Laurence
Miller Thomas A.
Witter David J.
Yan Jiaming
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
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