Histone deacetylase inhibitors

Details Histone deacetylase inhibitors Histone deacetylase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 403/04 (2006.01) A61K 31/397 (2006.01) A61K 31/403 (2006.01) A61K 31/407 (2006.01) A61P 35/00 (2006.01) C07D 209/52 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 417/14 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2605050

Compounds of formula: (I), and salts, N-oxides, hydrates and solvates thereof are histone deacetylase inhibitors and are useful in the treatment of cell proliferative diseases, including cancers: (I) wherein Q, V and W independently represent -N= or -C=; B is a divalent radical selected from: (IIA), (IIB), (IIC), (IID), and (IIE). Wherein the bond marked * is linked to the ring containing Q, V and W through -[Linker1]- and the bond marked ** is linked to A through -[Linker2]-; A is an optionally substituted mono-, bi- or tri-cyclic carbocyclic or heterocyclic ring system; and -[Linker1]- and - [Linker2]- independently represent a bond, or a divalent linker radical.

Composés de formule : (I), et leurs sels, N-oxydes, hydrates et solvates qui sont des inhibiteurs de l~histone désacétylase et sont utiles dans le traitement des maladies à prolifération cellulaire, y compris les cancers : (I) dans laquelle Q, V et W représentent indépendamment -N= ou -C=; B est un radical bivalent choisi parmi : (IIA), (IIB), (IIC), (IID), et (IIE); la liaison marquée * est liée à l~anneau contenant Q, V et W par l~intermédiaire du -[Lieur1]- et la liaison marquée ** est liée à A par l~intermédiaire du -[Lieur2]-; A est un système de cycle carbocyclique ou hétérocyclique mono-, bi- ou tricyclique substitué de façon facultative ; et le -[Lieur1]- et le -[Lieur2]- représentent indépendamment une liaison, ou un radical lieur bivalent.

Affiliated with

Also associated with

Rating

Histone deacetylase inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Histone deacetylase inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Histone deacetylase inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1937586