Histone deacetylase inhibitors based on...

Details Histone deacetylase inhibitors based on... Histone deacetylase inhibitors based on...

C - Chemistry, Metallurgy

07

C

C07C 49/255 (2006.01) A61K 31/121 (2006.01) C07C 49/227 (2006.01) C12Q 1/02 (2006.01)

Patent

CA 2486385

Histone deacetylase is a metallo-enzyme with zinc at the active site. Compounds having a zinc-binding moiety, for example, a trihalomethylcarbonyl group, such as a trifluoromethylcarbonyl group, can inhibit histone deacetylase. Histone deacetylase inhibition can repress gene expression, including expression of genes related to tumor suppression. Accordingly, inhibition of histone deacetylase can provide an alternate route for treating cancer, hematological disorders, e.g., hemaglobinopathies, autosomal dominant disorders, e.g. spinal muscular atrophy and Huntington's disease, genetic related metabolic disorders, e.g., cystic fibrosis and adrenoleukodystrophy, or for stimulating hematopoietic cellsex vivo.

L'histone désacétylase est une métallo-enzyme présentant du zinc au niveau du site actif. La présente invention concerne des composés présentant un groupe de liaison au zinc, par exemple un groupe trihalométhylcarbonyle, tel qu'un groupe trifluorométhylcarbonyle, qui peuvent inhiber l'histone désacétylase. L'inhibition d'histone désacétylase peut réprimer une expression génique, notamment l'expression de gènes liés à une suppression de tumeur. Ainsi, l'inhibition d'histone désacétylase peut offrir une alternative pour traiter des cancers, des troubles hématologiques, tels que des hémoglobinopathies, des troubles autosomiques dominants, tels qu'une amyotrophie spinale et la maladie de Huntington, des troubles métaboliques génétiques, tels qu'une mucovicidose et une leucodystrophie avec insuffisance surrénale, ou pour stimuler des cellules hématopoïétiques ex vivo.

Affiliated with

Also associated with

Rating

Histone deacetylase inhibitors based on... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Histone deacetylase inhibitors based on..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Histone deacetylase inhibitors based on... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1609315