Histone deacetylase inhibitors based on alpha-ketoepoxide...

Details Histone deacetylase inhibitors based on alpha-ketoepoxide... Histone deacetylase inhibitors based on alpha-ketoepoxide...

C - Chemistry, Metallurgy

07

D

C07D 303/32 (2006.01) A61K 31/335 (2006.01) A61K 31/336 (2006.01) C07D 303/12 (2006.01)

Patent

CA 2486303

Histone deacetylase is a metallo-enzyme with zinc at the active site. Compounds having a zinc-binding moiety, for example, an alpha-ketoepoxide group, such as an alpha-ketothio group, can inhibit histone deacetylase. Histone deacetylase inhibition can repress gene expression, including expression of genes related to tumor suppression. Accordingly, inhibition of histone deacetylase can provide an alternate route for treating cancer, hematological disorders, e.g., hemoglobinopathies, autosomal dominant disorders, e.g., spinal muscular atrophy and Huntington's disease, genetic related metabolic disorders, e.g., cystic fibrosis and adrenoleukodystrophy, or to stimulate hematopoietic cells ex vivo.

L'histone désacetylase est une métallo-enzyme comportant du zinc au niveau de son site actif. Les composés possédant un groupe caractéristique de liaison au zinc, par exemple un groupe alpha-céto-époxyde, tel qu'un groupe alpha-cétothio, peuvent inhiber l'histone désacétylase. L'inhibition de l'histone désacétylase peuvent réprimer l'expression de gènes, notamment l'expression de gènes associés à la suppression de tumeurs. En conséquence, l'inhibition de l'histone désacetylase peut constituer une voie détournée de traitement du cancer, des troubles hématologiques, tels que les hémoglobinopathies, des affections autosomiques dominantes, telles que la maladie d'Aran-Duchenne et la maladie de Huntington, des troubles métaboliques d'origine génétique, tels que la mucoviscidose et la leucodystrophie avec insuffisance surrénale, ou elle peut permettre la stimulation <i>ex vivo</i> de cellules hématopoïétiques.

Affiliated with

Also associated with

Rating

Histone deacetylase inhibitors based on alpha-ketoepoxide... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Histone deacetylase inhibitors based on alpha-ketoepoxide..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Histone deacetylase inhibitors based on alpha-ketoepoxide... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1487294