C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 259/06 (2006.01) A61K 31/165 (2006.01) A61K 31/166 (2006.01) A61K 31/351 (2006.01) A61K 31/4196 (2006.01) A61K 31/496 (2006.01) A61K 31/506 (2006.01) A61P 31/10 (2006.01)
Patent
CA 2633010
The present invention relates to compounds, compositions thereof and methods to selectively treat fungal infections More particularly this invention relates to compounds, compositions thereof and methods for selectively enhancing fungal sensitivity to antifungal compounds The compounds are hydroxamate-based inhibitors of histone deacetylase (HDAC) which show synergistic activity with antifungal agents against fungal species at concentrations of inhibitor non toxic to mammalian cells.
La présente invention concerne des compositions et des procédés pour traiter sélectivement une infection fongique. Plus particulièrement, cette invention concerne des compositions et des procédés pour augmenter sélectivement la sensibilité fongique à des composés antifongiques.
Ajamian Alain
Bedard Jean
Campeaol Nadia
Deziel Robert
Georgopapadakou Nafsika
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Methylgene Inc.
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