C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A61K 31/00 (2006.01) A61K 31/7088 (2006.01) A61P 25/00 (2006.01)
Patent
CA 2480016
The invention concerns the field of biology, genetics and medicine. In particular, it concerns novel methods for detecting, characterizing and/or treating neurodegenerative pathologies, in particular amyotrophic lateral sclerosis. The invention also concerns methods for identifying or screening compounds active in said pathologies. The invention further concerns compounds, genes, cells, plasmids or compositions useful for implementing said methods. In particular, the invention concerns the role of histones deacetylases, and particularly histone deacetylase 2, in said pathologies and its use as therapeutic, diagnostic or experimental target.
La présente invention concerne le domaine de la biologie, de la génétique et de la médecine. Elle concerne notamment de nouvelles méthodes pour la détection, la caractérisation et/ou le traitement de pathologies neurodégénératives, notamment de la sclérose latérale amyotrophique. L'invention concerne également des méthodes pour l'identification ou le screening de composés actifs dans ces pathologies. L'invention concerne également les composés, gènes, cellules, plasmides ou compositions utiles pour la mise en .oelig.uvre des méthodes ci-dessus. L'invention décrit notamment le rôle des histones déactétylases, et notamment l'histone déacétylase 2, dans ces pathologies et son utilisation comme cible thérapeutique, diagnostique ou expérimentale.
Resink Annelies
Schweighoffer Fabien
Exhonit Therapeutics Sa
Robic
LandOfFree
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