G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/574 (2006.01) A61P 35/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/15 (2006.01)
Patent
CA 2758933
The present invention provides methods of diagnosing and providing a prognosis and therapy for cancer including, but not limited to, pancreatic cancer and responsiveness to thymidylate synthase inhibitor (e.g., 5- FU) therapy, by identifying cancers with altered histone modification patterns selected from the group consisting of H3K4me2, H3K9me2, or H3K18ac.
La présente invention concerne des procédés de diagnostic, d'établissement d'un pronostic et de proposition d'un traitement en cas de cancer, par exemple en cas de cancer du pancréas, ainsi qu'un traitement impliquant la sensibilité à des inhibiteurs de la thymidylate synthase (par exemple le 5-FU), et ce en identifiant des cancers associés à des modèles de modification des histones modifiés, choisis dans le groupe constitué de H3K4me2, H3K9me2 ou H3K18ac.
Dawson David W.
Kurdistani Siavash K.
Seligson David B.
Smart & Biggar
The Regents Of The University Of California
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