Histophilus somni antigens, compositions and methods of use

Details Histophilus somni antigens, compositions and methods of use Histophilus somni antigens, compositions and methods of use

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) A61K 39/02 (2006.01) A61K 39/102 (2006.01) A61P 31/04 (2006.01) A61P 37/04 (2006.01) C07K 14/285 (2006.01) C07K 16/12 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2698307

This invention provides, among other things, protein, polypeptides, and fragments thereof, derived from bacteria Histophilus somni. Also provided are nucleic acids encoding for such proteins, polypeptides, and/or fragments, as well as nucleic acids complementary thereto. Additionally, this invention provides antibodies which bind to the proteins, polypeptides, and/or frag-ments. This invention further provides expression vectors useful for making the proteins, polypeptides, fragments, and/or nucleic acids, for use as vaccines, diagnostic reagents, immunogenic compositions, and the like. Methods of making the compositions and methods of treatment with the compositions are also provided. This invention also provides methods of detecting the proteins, polypeptides, fragments, variants and/or nucleic acids as well as detecting antibodies against the proteins, polypeptides, variants and fragments.

Cette invention propose, entre autres choses, une protéine, des polypeptides et des fragments de ceux-ci, dérivés de bactéries Histophilus somni. Il est également proposé des acides nucléiques codant de tels protéines, polypeptides et/ou fragments, ainsi que des acides nucléiques qui leur sont complémentaires. En outre, l'invention propose des anticorps qui se lient aux protéines, polypeptides et/ou fragments. L'invention propose en outre des vecteurs d'expression utiles pour préparer les protéines, polypeptides, fragments et/ou acides nucléiques, à utiliser comme vaccins, réactifs de diagnostic, compositions immunogènes et autres compositions. Des procédés de préparation des compositions et des procédés de traitement avec les compositions sont également proposés. Cette invention propose également des procédés de détection de protéines, polypeptides, fragments, variants et/ou acides nucléiques ainsi que de détection d'anticorps contre les protéines, polypeptides, variants et fragments.

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