Hiv-1 envelope glycoprotein oligomer and methods of use

Details Hiv-1 envelope glycoprotein oligomer and methods of use Hiv-1 envelope glycoprotein oligomer and methods of use

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 38/00 (2006.01) C07K 14/16 (2006.01) C12N 15/62 (2006.01)

Patent

CA 2705373

This invention relates to fusion polypeptides comprised of a trimerization domain fused to a non-membrane bound, non-cleaved gp160 polypeptide derived from the R2 HIV-1 Env glycoprotein and to compositions comprising the fusion polypep-tides. This invention further relates to oligomers of the fusion polypeptides. This invention also relates to nucleic acids encoding the fusion polypeptides. This invention also relates to diagnostic and therapeutic methods using the fusion polypeptides. Further, this invention relates to the induction of cross-reactive neutralizing antibodies against HIV-1, and to immunogenic compositions for the prevention and treatment of infection by HIV-1.

La présente invention porte sur des polypeptides de fusion composés d'un domaine de trimérisation fusionné à un polypeptide gp160 non clivé, non lié à la membrane, issu de la glycoprotéine Env du VIH-1 R2, et sur des compositions comprenant les polypeptides de fusion. Cette invention porte en outre sur des oligomères des polypeptides de fusion. Cette invention porte aussi sur des acides nucléiques codant pour les polypeptides de fusion. Cette invention porte également sur des procédés de diagnostic et thérapeutiques utilisant les polypeptides de fusion. En outre, cette invention porte sur l'induction d'anticorps neutralisant à réaction croisée contre le VIH-1, et sur des compositions immunogènes pour la prévention et le traitement d'une infection par le VIH-1.

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