Hiv-1 envelope glycoproteins having unusual disulfide structure

Details Hiv-1 envelope glycoproteins having unusual disulfide structure Hiv-1 envelope glycoproteins having unusual disulfide structure

A - Human Necessities

61

K

A61K 39/21 (2006.01) C12Q 1/70 (2006.01)

Patent

CA 2528005

The present invention provides HIV- I envelope glycoproteins having unusual disulfide structure. In particular, the invention includes gpl 20 polypeptides, and polynucleotides encoding such polypeptides, as well as related vectors, host cells, and expression methods. The invention also encompasses immunogenic compositions containing gp120 polypeptides or polynucleotides and their use in eliciting a gp120-specific immune response. gp120 polypeptides and polynucleotides of the invention are also useful in diagnostic methods of the invention.

L'invention concerne des glycoprotéines d'enveloppe du VIH-1 ayant une structure disulfure inhabituelle, en particulier des polypeptides gpl 20, et des polynucléotides codant ces polypeptides, ainsi que des vecteurs, des cellules hôtes et des procédés d'expression connexes. L'invention concerne également des compositions immunogènes renfermant des polypeptides ou des polynucléotides gp120, et leur utilisation pour induire une réponse immunitaire gp120-spécifique. Les polypeptides et polynucléotides gp120 considérés sont également utiles pour la mise en oeuvre de procédés diagnostiques décrits dans l'invention.

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