Hiv-1 prophylactic composition and method

Details Hiv-1 prophylactic composition and method Hiv-1 prophylactic composition and method

A - Human Necessities

61

K

A61K 39/21 (2006.01) A61K 39/39 (2006.01) C07F 9/06 (2006.01) C07K 14/16 (2006.01) C08G 79/02 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2223599

A composition and method for inducing a protective immune response to HIV-1 in an individual, of (a) a replication incompetent HIV-1, HIV-1 pseudovirus, HIV- 1 VLP or oligomeric gp120; and (b) a water-soluble polyphosphazene polyelectrolyte, wherein (a) and (b)are present in an amount effective to induce a protective immune response against HIV-1.

Composition et procédé servant à provoquer une réaction immune de protection contre le VIH-1 chez un individu. Ladite composition comprend (a) un VIH-1 incapable de réplication, un pseudovirus VIH-1, un VLP ou gp120 oligomère de VIH-1 et (b) un polyélectrolyte de polyphosphazène soluble dans l'eau, (a) et (b) étant présents en une dose efficace pour provoquer une réaction immune de protection contre le VIH-1.

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