Hiv and cd4 transgenic animals and uses therefor

Details Hiv and cd4 transgenic animals and uses therefor Hiv and cd4 transgenic animals and uses therefor

C - Chemistry, Metallurgy

12

Q

C12Q 1/70 (2006.01) A01K 67/027 (2006.01) C07K 14/16 (2006.01) C07K 14/73 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2461823

The invention provides transgenic animals comprising a lentiviral transgene, such as an HIV transgene. Also within the scope of the invention are cells and eggs from the transgenic animal. Further included are methods for identifying therapeutic compounds for preventing lentiviral infection and treating associated disease (e.g. AIDS).

L'invention concerne des animaux transgéniques comprenant un transgène lentiviral, tel qu'un transgène du VIH. L'invention concerne également des cellules et des oeufs provenant de ces animaux transgéniques. Font aussi l'objet de cette invention des procédés d'identification de composés thérapeutiques permettant de prévenir une infection lentivirale et de traiter des maladies associées, notamment le SIDA.

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