Hiv antigen

Details Hiv antigen Hiv antigen

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 39/21 (2006.01) C07K 14/155 (2006.01) C07K 14/16 (2006.01) C07K 19/00 (2006.01) C12N 15/49 (2006.01) C12N 15/73 (2006.01) G01N 33/569 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2084386

Disclosed is a substantially pure HIV antigen comprising a Gag-Env fusion protein consisting of a Gag peptide fused at its C-terminus to an Env peptide, wherein the Gag peptide comprises a contiguous sequence of at least ten amino acids of the amino acid sequence represented by Gag (308-437) and the Env peptide comprises a contiguous sequence of at least a part of the amino acid sequence represented by Env (512-699), the part containing at least one epitope which is reactive to an HIV antibody. The gag-env fusion DNA corresponding to the HIV antigen of the present invention allows the production of the desired high antigenicity HIV antigen in high yield. Therefore, the HIV antigen of the present invention can be advantageously used as an active component for a diagnostic reagent, a vaccine, an antibody preparation and a therapeutic reagent for AIDS. Also disclosed is a substantially pure HIV antigen comprising a Gag protein coded for by the entire gag gene.

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