Hiv-dependent expression constructs and uses therefor

Details Hiv-dependent expression constructs and uses therefor Hiv-dependent expression constructs and uses therefor

C - Chemistry, Metallurgy

12

N

C12N 15/48 (2006.01) A61K 48/00 (2006.01) C12N 5/10 (2006.01) C12N 15/867 (2006.01) C12N 15/90 (2006.01) C12Q 1/04 (2006.01) C12Q 1/68 (2006.01) C12Q 1/70 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2540253

The present invention provides nucleic acid molecules comprising expressible sequences, including reporter genes and therapeutic genes, whose expression is dependent on the presence of both HIV Tat and Rev proteins. Further provided are methods for detecting HIV, method for identifying compounds that can inhibit HIV infection and/or gene expression, methods for killing HIV-infected cells, and methods of treating HIV-infected subjects.

L'invention se rapporte à des molécules d'acide nucléique contenant des séquences expressibles, qui comprennent des gènes rapporteurs et des gènes thérapeutiques, dont l'expression dépend de la présence des deux protéines Tat et Rev VIH. L'invention porte aussi sur des procédés de détection du VIH, sur des procédés d'identification de composés qui peuvent inhiber l'infection VIH/ et/ou l'expression génique, sur des procédés permettant d'éliminer des cellules infectées au VIH, et sur des procédés de traitement de sujets atteints du VIH.

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