Hiv envelope polypeptides and vaccine

Details Hiv envelope polypeptides and vaccine Hiv envelope polypeptides and vaccine

C - Chemistry, Metallurgy

12

N

C12N 15/49 (2006.01) A61K 39/21 (2006.01) C07K 14/035 (2006.01) C07K 14/16 (2006.01) C07K 19/00 (2006.01) C12N 15/38 (2006.01) C12N 15/62 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2259965

Oligonucleotide sequences encoding gp120 polypeptides from breakthrough isolates of vaccine trials using MN-rgp120 and the encoded gp120 polypeptides are provided. Use of the gp120 polypeptides from one or more of the isolates in a subunit vaccine, usually together with MN-rgp120, can provide protection against HIV strains that are sufficiently different from the vaccine strain (e.g.; MN-rgp120) that the vaccine does not confer protection against those strains. Antibodies induced by the polypeptides are also provided.

L'invention concerne des séquences oligonucléotidiques codant les polypeptides gp120 issus des isolats découverts dans les essais de vaccin, sur la base de polypeptides MN-rgp120 et de polypeptides codés gp120. L'utilisation des polypeptides gp120 issus d'un ou de plusieurs isolats dans un vaccin sous-unitaire, généralement en combinaison avec les polypeptides MN-rgp120, offrent une protection contre les souches du HIV qui sont suffisamment différentes de la souche du vaccin (par exemple, MN-rgp120) pour que le vaccin n'assure pas la protection contre ces souches. L'invention concerne également des anticorps induits par les polypeptides.

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