Hiv-gag codon-optimised dna vaccines

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/48 (2006.01) A61P 31/18 (2006.01) C07K 14/16 (2006.01) C12N 15/09 (2006.01) C12N 15/49 (2006.01) C12N 15/869 (2006.01)

Patent

CA 2461056

The invention provides a nucleotide sequence that encodes an HIV-1 gag protein or fragment thereof containing a gag epitope and a second HIV antigen or a fragment encoding an epitope of said second HIV antigen, operably linked to a heterologous promoter. Preferred polynucleotide sequences further encodes nef or a fragment thereof and RT or a fragment thereof.

L'invention concerne une séquence nucléotidique codant une protéine gag VIH-1 ou son fragment contenant un épitope gag et un second antigène VIH ou un fragment codant un épitope du second gène VIH, lié de manière opérationnelle à un promoteur hétérologue. De préférence, des séquences polynucléotidiques codent nef ou son fragment et RT ou son fragment.

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