C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 253/06 (2006.01) A61K 31/53 (2006.01) A61P 31/18 (2006.01)
Patent
CA 2575002
The present invention relates to HIV replication inhibitors of formula (I) a N- oxide, a pharmaceutically acceptable addition salt, a quaternary amine or a stereochemically isomeric form thereof, wherein ring A and ring B represent phenyl, pyridyl, pyridazinyl, pyrimidinyl or pyrazinyl; n and m are 1 to 4; R1 represents hydrogen; aryl; formyl; C1-6alkylcarbonyl; C1-6alkyloxycarbonyl; optionally substituted C1-6alkyl; C1-6alkyloxy C1-6alkylcarbonyl substituted with C1-6alkyloxycarbonyl; their use as a medicine, their use for the manufacture of a medicament for the treatment or the prevention of HIV infection; their processes for preparation and pharmaceutical compositions comprising them.
La présente invention porte sur des inhibiteurs de réplication du VIH de la formule (I), un oxyde N, un sel d~addition acceptable pharmaceutiquement, un amine quaternaire ou une forme isomère stéréochimique de celui-ci, où l~anneau A et l~anneau B représentent le phényle, le pyridyle, le pyridazinyle, le pyrimidinyle ou le pyrazinyle ; n et m sont 1 à 4; R1 représente l~hydrogène ; un aryle ; un formyle ; un alkyle carbonyle C1-6 ; un alkyloxycarbonyle C1-6 ; éventuellement un alkyle substitué C1-6 ; un alkyloxy C1-6 alkyle carbonyle C1-6 substitué par un alkyloxycarbonyle C1-6 ; leur utilisation comme médicament, leur utilisation pour la fabrication d~un médicament pour le traitement ou la prévention de l~infection VIH ; leurs procédés de fabrication et les compositions pharmaceutiques les comprenant.
Daeyaert Frederik Frans Desire
de Jonge Marc Rene
Heeres Jan
Hoornaert Georges Joseph Cornelius
Janssen Paul Adriaan Jan
Gowling Lafleur Henderson Llp
Janssen Pharmaceutica N.v.
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