Hiv integrase inhibitors

Details Hiv integrase inhibitors Hiv integrase inhibitors

A - Human Necessities

61

K

A61K 31/535 (2006.01) A01N 37/08 (2006.01) A01N 37/12 (2006.01) A01N 43/02 (2006.01) A01N 43/06 (2006.01) A01N 43/26 (2006.01) A01N 43/32 (2006.01) A01N 43/38 (2006.01) A01N 43/40 (2006.01) A01N 43/54 (2006.01) A01N 43/58 (2006.01) A01N 43/60 (2006.01) A01N 43/64 (2006.01) A01N 43/76 (2006.01) A01N 43/82 (2006.01) A01N 53/00 (2006.01) C07C 59/74 (2006.01) C07C 59/76 (2006.01) C07C 59/84 (2006.01) C07C 59/86 (2006.01) C07C 59/88 (2006.01) C07C 59/90 (2006.01) C07C 69/738 (2006.01) C07C 69/76 (2006.01) C07C 2

Patent

CA 2333707

Certain six-membered aromatic and heteroaromatic-dioxo-butyric acid derivatives are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.

Cette invention a trait à certains dérivés d'acide dioxo-butyrique à 6 chaînons, aromatique et hétéro-aromatique, agissant en tant qu'inhibiteurs de VIH intégrase et de la réplication du VIH. Ces composés sont utilisés dans le cadre de la prévention et du traitement des infections par le VIH et du sida, que ce soit sous forme de composés, de sels acceptables du point de vue pharmaceutique ou d'ingrédients de composition pharmaceutique, seuls ou associés à d'autres antiviraux, immunorégulateurs, antibiotiques ou vaccins. L'invention concerne également des méthodes de traitement du sida ainsi que des méthodes de prévention et de traitement des infections par VIH.

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