C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 498/10 (2006.01) A61K 31/527 (2006.01) A61P 31/18 (2006.01) C07D 471/10 (2006.01) C07D 487/10 (2006.01) C07D 491/20 (2006.01) C07D 498/20 (2006.01)
Patent
CA 2566755
The invention encompasses a series of pyrimidinone compounds which inhibit HIV integrase and thereby prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses intermediates useful for making the pyrimidone compounds. Additionally, pharmaceutical compositions and methods for treating those infected with HIV are encompassed. Formula (I).
L~invention concerne une série de composés de la pyrimidinone qui inhibe l~intégrase du VIH et empêchent ainsi l~intégration virale dans l~ADN humain. Cette action rend les composés utiles pour traiter l~infection VIH et le SIDA. L~invention concerne également des intermédiaires utiles pour fabriquer les composés de la pyrimidone. De plus, des compositions pharmaceutiques et des procédés de traitement des personnes infectées par le VIH sont compris. Formule (I).
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
LandOfFree
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