Hiv integrase inhibitors from pyridoxine

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 213/81 (2006.01) A61K 31/44 (2006.01) A61K 31/4427 (2006.01) A61P 31/12 (2006.01) A61P 31/18 (2006.01) C07D 405/12 (2006.01) C07D 493/04 (2006.01)

Patent

CA 2726742

The present invention relates to pyridoxine (vitamin B6) derived compounds of formula (I), pharmaceutically acceptable salts, or solvates thereof, wherein R1, R2, R4, A, L B1 and B2 are as defined in the specification, and pharmaceutical compositions comprising the compounds. Compounds of formula (I) inhibit Human Immunodeficiency Virus (HIV)-integrase enzyme and are useful for preventing and treating HIV infection and AIDS.

La présente invention porte sur des composés issus de la pyridoxine (vitamine B6) de formule (I), sur des sels pharmaceutiquement acceptables ou solvates de ceux-ci, formule dans laquelle R1, R2, R4, A, L, B1 et B2 sont tels que définis dans la description, et sur des compositions pharmaceutiques comprenant les composés. Les composés de formule (I) inhibent l'enzyme intégrase du virus de l'immunodéficience humaine (VIH) et sont utiles pour prévenir et traiter une infection par le VIH et le SIDA.

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