C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 21/08 (2006.01)
Patent
CA 2046016
-1- A monoclonal antibody is described capable of binding to a glycoprotein antigen having a molecular weight of about 12 x 10 4 daltons (gp120) present in the envelope of human immunodeficiency virus (HIV) and capable of substantially neutralizing the HIV, or fragments thereof. It has the characteristics of immunoglobulin class IgG, k, being capable of binding to glycoprotein antigen having a molecular weight of 12 x 10 4 daltons (gp120) of HTLV-III MN, being capable of recognizing at least one epitope which is present in the region of the amino acid sequence 303 to 325 of gp120 of HTLV-III MN, being capable of binding to the surface of HTLV-III MN viral particles and thereby inhibiting the infection of the viral particles to CD4-positive cells, and being capable of binding to the surface of cells infected with HTLV-III MN and thereby inhibiting the syncytium formation induced by interaction between the infected cells and uninfected cells. The monoclonal antibody is useful for the prophylaxis, treatment and diagnosis of AIDS.
Eda Yasuyuki
Hattori Toshio
Matsushita Shuzo
Osatomi Kiyoshi
Shiosaki Kouichi
Juridical Foundation The Chemo-Sero-Therapeutic Research Institu
Kirby Eades Gale Baker
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