C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
167/103.05, 530/
C07K 5/02 (2006.01) A61K 38/04 (2006.01) A61K 38/07 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2036398
Disclosed herein are compounds of the general formula X-A-B-C-D-Y wherein X is a terminal group, for example, alkanoyl or phenylalkanoyl radicals, A is an amino acid residue having a lower alkyl or lower cycloalkyl side chain, e.g. Ala or Val, B is a non-peptide linking unit, e.g. statyl or Phe~[CH2NH]Leu, C is an amino acid residue of .alpha.-amino-.beta.-cycloalkylpropionic acid, glutamic acid or .alpha.-aminoadipic acid, or a related derivative thereof, D is an amino-acid residue, for example, Phe or Val, and Y is hydroxy, alkoxy, amino, alkylamino or dialkylamino. The compounds inhibit the activity of human immunodeficiency virus (HIV) protease and interfere with HIV induced cytopathogenic effects in human cells. These properties render the compounds useful for combating HIV infections.
Anderson Paul Cates
Guindon Yvan
Moss Neil
Poupart Marc-Andre
Yoakim Christiane
Boehringer Ingelheim (canada) Ltd. Boehringer Ingelheim (canada)
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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