Hiv protease inhibitors

Details Hiv protease inhibitors Hiv protease inhibitors

C - Chemistry, Metallurgy

07

K

167/103.05, 530/

C07K 5/02 (2006.01) A61K 38/05 (2006.01) C07C 271/22 (2006.01) C07C 311/37 (2006.01) C07C 323/32 (2006.01) C07K 5/06 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2036413

Disclosed herein are compounds of the general formula X-A-B-Y wherein X is R1OC(O), R1NHC(O) or R1C(O) wherein R1 is, for example, alkyl, optionally substituted phenyl or optionally substituted benzyl, A is a non-peptide linking unit, e.g. statyl or Phe~[CH2NH]Leu, B is an amino acid residue of glutamic acid or a related derivative thereof, and Y is alkoxy, cycloalkoxy, a substituted alkoxy or a substituted amino group, e.g. cycloalkyl-alkoxy, aralkoxy, alkylamino, (cycloalkyl)alkylamino or aralkylamino. The compounds inhibit the activity of human immunodeficiency virus (HIV) protease and interfere with HIV induced cytopathogenic effects in human cells. These properties render the compounds useful for combating HIV infections.

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