Hiv protease inhibitors based on amino acid derivatives

Details Hiv protease inhibitors based on amino acid derivatives Hiv protease inhibitors based on amino acid derivatives

C - Chemistry, Metallurgy

07

C

C07C 311/19 (2006.01) A61K 31/18 (2006.01) A61K 31/198 (2006.01) A61K 31/381 (2006.01) A61K 31/405 (2006.01) A61K 31/5375 (2006.01) A61K 31/63 (2006.01) A61P 31/18 (2006.01) C07C 311/29 (2006.01) C07C 311/46 (2006.01) C07D 209/18 (2006.01) C07D 295/215 (2006.01) C07D 333/34 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07K 5/02 (2006.01)

Patent

CA 2440931

A compound selected from the group consisting of a compound of formula I or formula II: (I) (II) wherein n is 3 or 4 wherein Cx is selected from the group consisting of -COOM, COOR6, -CHO, -CH2OR7, -CH2OCOR8, -CONHR9 and -CONR10R11, wherein M is an alkali metal or alkaline earth metal, wherein R2 is selected from the group consisting of a benzenesulfonyl group of formula III, or formula IV : (III) (IV) and when the compound of formula (I) and (II) comprises an amino group pharmaceutically acceptable ammonium salts thereof, wherein R1, R2, Cx, n, R3, R4, R5, Y are as defined in the specification.

L'invention concerne un composé sélectionné dans le groupe constitué d'un composé de formule (I) ou de formule (II) dans laquelle n désigne 3 ou 4, Cx est sélectionné dans le groupe -COM, COR¿6?, -CHO, -CH¿2?OR¿7?, -CH¿2?OCOR¿8?, -CONHR¿9? et -CONR¿10?R¿11?, M désigne un métal alcalin ou un métal alcalino-terreux, R¿2? sélectionné dans le groupe constitué d'un groupe de benzènesulfonyle de formule (III) ou de formule (IV). Lorsque le composé de formule (I) et (II) referme un groupe aminé et ses sels d'ammonium pharmaceutiquement acceptables, R¿1?, R¿2?, Cx, n, R¿3?, R¿4?, R¿5?, Y sont tels que définis dans les revendications.

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