Hiv protease inhibitors, compositions containing the same,...

C - Chemistry – Metallurgy – 07 – D

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C07D 277/06 (2006.01) A61K 31/426 (2006.01) A61P 31/18 (2006.01)

Patent

CA 2450269

Compounds of formula (I) where the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the HIV protease. Theses compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with the HIV virus. Intermediates and synthetic methods for preparing such compounds are also described.

L'invention concerne des composés représentés par la formule (I) dans laquelle les variables sont telles que définies dans le descriptif, qui inhibent ou bloquent avantageusement l'activité biologique de la protéase du HIV. Ces composés ainsi que des compositions pharmaceutiques contenant ceux-ci, sont utiles pour traiter des patients ou des hôtes contaminés par le virus HIV. L'invention concerne également des produits intermédiaires et des procédés de synthèse pour préparer ces composés.

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