Hiv protease inhibitors having symmetrical structure

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 295/155 (2006.01) A61K 31/165 (2006.01) A61K 31/35 (2006.01) A61K 31/38 (2006.01) A61K 31/535 (2006.01) A61K 31/66 (2006.01) C07C 235/36 (2006.01) C07D 235/14 (2006.01) C07D 295/092 (2006.01) C07D 311/68 (2006.01) C07D 311/76 (2006.01) C07D 335/06 (2006.01) C07D 413/14 (2006.01) C07F 9/02 (2006.01)

Patent

CA 2052907

61/RDM32 68/RDM39 18236 TITLE OF THE INVENTION HIV PROTEASE INHIBITORS HAVING SYMMETRICAL STRUCTURE ABSTRACT OF THE DISCLOSURE Compounds of the form, J-B-B-G-B-B-J wherein G is a dipeptide isostere, B an amino acid or analog thereof, and J a small terminal group are described. These compounds are useful in the inhibition of HIV protease, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other 61/RDM32 68/RDM39 - i - 18236 antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.

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