Hiv protease inhibitors useful for the treatment of aids

Details Hiv protease inhibitors useful for the treatment of aids Hiv protease inhibitors useful for the treatment of aids

C - Chemistry, Metallurgy

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C07D 295/15 (2006.01) A61K 31/27 (2006.01) A61K 31/395 (2006.01) C07C 237/22 (2006.01) C07C 271/22 (2006.01) C07D 213/74 (2006.01) C07D 235/14 (2006.01) C07D 295/092 (2006.01) C07D 295/155 (2006.01) C07D 295/215 (2006.01) C07D 307/16 (2006.01) C07D 307/20 (2006.01) C07D 307/24 (2006.01) C07D 307/33 (2006.01) C07D 307/42 (2006.01) C07D 307/54 (2006.01) C07D 309/04 (2006.01) C07D 309/08 (2006.01) C07D 309/12 (2006.01) C07D 311/68 (2006.01) C07D 317/24 (2006.01) C07D 319/20 (2006.01) C07D 335/06 (2006.01) C07D

Patent

CA 2032259

71/RDM40 72/RDM41 73/RDM42 74/RDM43 77/RDM44 18025IA TITLE OF THE INVENTION HI PROTEASE INHIBITORS USEFUL FOR THE TREATMENT OF AIDS ABSTRACT OF THE DISCLOSURE Compounds of the form, A-G-B-B-J wherein A is an amine protecting group or urethane, G a dipeptide isostere substituted with a basic amine nitrogen, B an amino acid or analog thereof, and J a small terminal group are described. These compounds are useful in the inhibition of HIV protease, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, 71/RDM40 - i - 18025IA pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.

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