Hiv protease inhibitors with n-terminal polyether substituents

Details Hiv protease inhibitors with n-terminal polyether substituents Hiv protease inhibitors with n-terminal polyether substituents

C - Chemistry, Metallurgy

07

C

C07C 271/20 (2006.01) A61K 31/27 (2006.01) A61K 31/33 (2006.01) A61K 31/66 (2006.01) C07C 235/16 (2006.01) C07C 271/22 (2006.01) C07C 317/50 (2006.01) C07C 323/50 (2006.01) C07D 213/56 (2006.01) C07D 233/64 (2006.01) C07D 235/14 (2006.01) C07D 307/54 (2006.01) C07D 333/24 (2006.01) C07F 9/02 (2006.01)

Patent

CA 2076204

85/RDM48 132/RDM70 18380 TITLE OF THE INVENTION HIV PROTEASE INHIBITORS WITH N-TERMINAL POLYETHER SUBSTITUENTS ABSTRACT OF THE DISCLOSURE Compounds of the form A-G-B-B-J wherein A is a polyether or ether substituent, G is a dipeptide isostere, B an amino acid or analog thereof, and J a small terminal group are described. These compounds are useful in the inhibition of HIV protease, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.

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