Hiv replication inhibiting purine derivatives

Details Hiv replication inhibiting purine derivatives Hiv replication inhibiting purine derivatives

C - Chemistry, Metallurgy

07

D

C07D 473/16 (2006.01) A61K 31/52 (2006.01) A61P 31/18 (2006.01) C07D 473/00 (2006.01) C07D 473/18 (2006.01)

Patent

CA 2535313

The present invention relates to the use of a compound of formula (I) for the manufacture of a medicament for the prevention or the treatment of HIV infection wherein the compound of formula (I) is a compound of formula (I) a N- oxide, a pharmaceutically acceptable addition salt, a quaternary amine or a stereochemically isomeric form thereof, wherein A and B each represents a radical of formula (a) or (b) and wherein -C-D- represents a bivalent radical of formula -N=CH-NR17- (c-1); or -NR17-CH=N- (c-2); provided that when A represents a radical of formula (a) then B represents a radical of formula (b) and when A represents a radical of formula (b) then B represents a radical of formula (a).

L'invention concerne l'utilisation d'un composé de formule (I) pour produire un médicament servant à prévenir ou traiter une infection par le VIH. Selon l'invention : le composé de formule (I) est un composé de formule (I) ou un <I>N</I>-oxyde, un sel d'addition pharmaceutiquement acceptable, une amine quaternaire ou une forme stéréo-isomère de celui-ci ; A et B représentent respectivement un radical de formule (a) ou (b), et ; -C-D- désigne un radical bivalent de formule -N=CH-NR?17¿- (c-1) ou -NR?17¿-CH=N- (c-2) ; à condition que lorsque A désigne un radical de formule (a), B représente un radical de formule (b), et que lorsque A désigne un radical de formule (b), B représente un radical de formule (a).

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