Hiv replication inhibiting pyrimidines and triazines

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 239/46 (2006.01) A61K 31/505 (2006.01) A61P 31/18 (2006.01) C07D 239/48 (2006.01) C07D 251/16 (2006.01) C07D 251/50 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2406562

This invention concerns HIV replication inhibitors of for-mula (I)the N-oxides, the pharmaceutically acceptable addition salts, the quaternary amines and the stereochemically isomeric forms thereof, pro-vided that when Q is halo then Z is N; or when Q is polyhaloC1-6alkyl then Y is hydrogen or C1-6alkyl; their use as a medicine, their processes for preparation and pharmaceutical compositions comprising them.

L'invention concerne des inhibiteurs de la réplication du VIH selon la formule (I), des N-oxydes, les sels d'addition pharmaceutiquement acceptables, les amines quaternaires et les formes stéréochimiquement isomériques de ces derniers. Lorsque Q représente halo, Z représente N ou lorsque Q représente polyhaloalkyleC1-6 alors Y représente hydrogène ou alkyle C1-6. L'invention traite de l'utilisation de ces composés comme médicaments, de leurs procédés de préparations et de compositions pharmaceutiques les contenant.

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