Hiv reverse transcriptase inhibitors

C - Chemistry – Metallurgy – 07 – C

Patent

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Details

C07C 311/29 (2006.01) A61K 31/437 (2006.01) A61P 31/12 (2006.01) C07C 253/30 (2006.01) C07C 311/59 (2006.01) C07D 209/08 (2006.01) C07D 213/65 (2006.01) C07D 213/75 (2006.01) C07D 231/56 (2006.01) C07D 235/06 (2006.01) C07D 249/04 (2006.01) C07D 263/56 (2006.01) C07D 271/10 (2006.01) C07D 277/64 (2006.01) C07D 333/48 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2615019

Compounds having the structure: are HIV reverse transcriptase inhibitors, wherein A, X, Y, Z, R1 and R2 are defined herein. The compounds and their pharmaceutically acceptable salts are useful in the inhibition of HIV reverse transcriptase, the prophylaxis and treatment of infection by HIV and in the prophylaxis, delay in the onset, and treatment of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

Les composés représentés par la structure (I) sont des inhibiteurs de la transcriptase inverse du VIH. Dans ladite formule, A, X, Y, Z, R1 et R2 sont tels que définis dans la description. Les composés et leurs sels pharmaceutiquement acceptables sont utiles dans l'inhibition de la transcriptase inverse du VIH, dans la prophylaxie et le traitement d'une infection par le VIH ainsi que dans la prophylaxie, le retardement de l'apparition et le traitement du SIDA. Lesdits composés et leurs sels peuvent être utilisés en tant qu'ingrédients dans des compositions pharmaceutiques, éventuellement en combinaison avec d'autres antiviraux, immunomodulateurs, antibiotiques ou vaccins.

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