Hiv tat-cd4 hybrid molecules and methods of use thereof

Details Hiv tat-cd4 hybrid molecules and methods of use thereof Hiv tat-cd4 hybrid molecules and methods of use thereof

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01) C12N 15/09 (2006.01) C12N 15/12 (2006.01) C12N 15/62 (2006.01)

Patent

CA 2597040

Hybrid molecules comprising CD4 minimal modules or mimetics that bind to HIV Env polypeptides in combination with one or more HIV Tat polypeptides are described. Also described are complexes of these hybrid molecules with Env as well as methods of diagnosis, treatment and prevention using the polynucleotides and polypeptides.

La présente invention concerne des molécules hybrides comprenant des modules minimaux CD4 ou des mimétiques qui se lient aux polypeptides HIV Env conjointement avec un ou plusieurs polypeptides HIV Tat. Cette invention concerne également des complexes de ces molécules hybrides associées à Env, ainsi que des méthodes de diagnostic, de traitement et de prévention consistant à utiliser les polynucléotides et les polypeptides.

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