C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C07H 21/00 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2479530
The present invention provides siRNA methods and compositions for inhibiting HIV and/or replication, as well as systemsfor identifying effective siRNAs for inhibiting HIV and systems for studying HIV infective mechanisms. The invention also provides methods and compositions for inhibiting infection, pathogenecityand/or replication of an infectious agent; for example, by using siRNAs to inhibit host cell gene expression.
L'invention concerne des procédés et des compositions d'ARNsi destinés à inhiber le VIH et/ou sa réplication, des systèmes d'identification d'ARNsi efficaces permettant d'inhiber le VIH et des systèmes d'étude des mécanismes de l'infection par le VIH. L'invention concerne aussi des procédés et des compositions destinés à inhiber l'infection, la pathogénicité et/ou la réplication d'un agent infectieux, par l'utilisation, par exemple, d'ARNsi afin d'inhiber l'expression génétique de cellule hôte.
Beresford Paul J.
Lieberman Judy
Murray Michael F.
Novina Carl D.
Sharp Phillip A.
Brigham And Women's Hospital Inc.
Massachusetts Institute Of Technology
Robic
The Center For Blood Research Inc.
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