Hiv vaccines based on env of multiple clades of hiv

Details Hiv vaccines based on env of multiple clades of hiv Hiv vaccines based on env of multiple clades of hiv

A - Human Necessities

61

K

A61K 39/12 (2006.01) C07K 14/16 (2006.01)

Patent

CA 2539068

In one embodiment, the invention provides a multiclade HIV plasmid DNA or viral vector vaccine including components from different clades fo Env (optionally Env chimeras) and Gag-Pol-(optionally)Nef from a single clade. The vaccine of the invention may further include V1, V2, V3, or V4 deletions or combinations thereof. In another embodiment, the invention provides multiclade HIV envelope immunogens.

Dans un mode de réalisation, l'invention concerne un ADN de plasmide VIH multiclade ou un vaccin de vecteur de virus comprenant des composants provenant de différentes variantes d'Env (éventuellement des chimères Env) et des Gag-Pol (éventuellement)Nef d'une variante. Le vaccin de l'invention peut également comprendre des délétions de V1, V2, V3, ou V4 ou leurs combinaisons. Dans un autre mode de réalisation, l'invention concerne des immunogènes d'enveloppe pour des VIH multiclades.

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