Hla-a*1101-restricted wt1 peptide and pharmaceutical...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) A61P 35/02 (2006.01) C07K 14/82 (2006.01) C12Q 1/02 (2006.01) G01N 33/574 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2670658

Disclosed are: an HLA-A*-1101-restricted WT1 peptide, specifically a peptide which comprises an amino acid sequence composed of nine contiguous amino acid residues derived from WT1 protein, is capable of binding to an HLA-A* 1101 molecule and has a CTL-inducing ability; a peptide dimer which comprises two peptide monomers each comprising an amino acid sequence composed of nine contiguous amino acid residues containing at least one cysteine residue and derived from WT1 protein, wherein the two peptide monomers are linked to each other via a disulfide bond and the peptide dimer is capable of binding to an HLA-A* 1101 molecule and has a CTL-inducing ability; a polynucleotide encoding the peptide; a pharmaceutical composition for the treatment and/or prevention of cancer, which comprises the peptide or the peptide dimer; and others.

L'invention a pour objet, entre autres, un peptide WT1 à restriction HLA-A*-1101, plus précisément un peptide contenant une séquence d'acides aminés composée de neuf résidus acides aminés contigus dérivant de la protéine WT1, ce peptide étant capable de se lier à une molécule HLA-A* 1101 et d'induire des lymphocytes T cytotoxiques ; un peptide dimère comportant deux monomères peptidiques comprenant chacun une séquence d'acides aminés composées de neuf résidus acides aminés contigus contenant au moins un résidu cystéine et dérivant de la protéine WT1, les deux monomères peptidiques étant liés l'un à l'autre par l'intermédiaire d'une liaison disulfure et le peptide dimère étant capable de se lier à une molécule HLA-A* 1101 et d'induire des lymphocytes T cytotoxiques ; un polynucléotide codant le peptide ; une composition pharmaceutique, contenant le peptide ou le peptide dimère, destinée au traitement et/ou à la prévention du cancer.

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