Hla-a2.1 binding peptides and their uses

Details Hla-a2.1 binding peptides and their uses Hla-a2.1 binding peptides and their uses

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) C07H 21/04 (2006.01) C07K 14/02 (2006.01) C07K 14/03 (2006.01) C07K 14/08 (2006.01) C07K 14/11 (2006.01) C07K 14/16 (2006.01) C07K 14/18 (2006.01) C07K 14/47 (2006.01) C07K 16/00 (2006.01) C12N 9/90 (2006.01)

Patent

CA 2420225

The present invention provides the means and methods for selecting immunogenic peptides and the immunogenic peptide compositions capable of specifically binding glycoproteins encoded HLA-A2.1 allele and inducing T cell activation in T cells restricted by the A2.1 allele. The peptides are useful to elicit an immune response against a desired antigen.

La présente invention concerne des moyens et des méthodes permettant de sélectionner des peptides immunogènes, ainsi que des compositions de peptides immunogènes capables de se fixer de façon spécifique sur des glycoprotéines codées par l'allèle HLA-A2.1 et de provoquer l'activation des lymphocytes T dans des lymphocytes T soumis à une restriction par l'allèle A2.1. Ces peptides sont utiles pour déclencher une réponse immune contre un antigène souhaité.

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