C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C12Q 1/02 (2006.01) G01N 33/15 (2006.01) G01N 33/543 (2006.01) C12P 19/34 (2006.01)
Patent
CA 2651954
This invention relates to a method of determining the presence of certain HLA alleles, such as HLA-B*1502 or HLA-B*5801, and a kit for carrying out this method. Also disclosed is a method for assessing whether a patient is at risk for developing adverse drug reactions (e.g., Stevens-Johnson syndrome, toxic epidermal necrolysis, or hypersensitivity syndrome) based on the presence or absence of a genetic marker (e.g., HLA-B*1502, HLA-B*5801, or HLA-B*4601).
L'invention concerne un procédé permettant de déterminer la présence de certains allèles de HLA, tels que HLA-B*1502 ou HLA-B*580, et un kit permettant de mettre en oeuvre ledit procédé. L'invention concerne également un procédé permettant d'évaluer le risque qu'un patient développe des réactions indésirables à un médicament (p. ex. Syndrome de Stevens-Johnson, nécrolyse épidermique toxique ou syndrome d'hypersensibilité) basées sur la présence ou l'absence d'un marqueur génétique (p. ex. HLA-B*1502, HLA-B*5801 ou HLA-B*4601).
Chang Chi-Feng
Chen Wei-Hsuan
Chen Yuan-Tsong
Hung Shuen-Lu
Lin Hsin-Yu
Academia Sinica
Gowling Lafleur Henderson Llp
Pharmigene Inc.
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