Hla-dr binding peptides and their uses

Details Hla-dr binding peptides and their uses Hla-dr binding peptides and their uses

C - Chemistry, Metallurgy

07

K

C07K 14/435 (2006.01) A61K 38/00 (2006.01) C07K 7/00 (2006.01) C07K 14/00 (2006.01) C07K 14/72 (2006.01) C07K 14/725 (2006.01)

Patent

CA 2704397

The present invention provides HLA-DR (MHC class II) binding peptides derived from the ovarian/breast cancer associated antigens, Human Epidermal Growth Factor Receptor 2 (HER-2/neu), Carcinoembryonic Antigen (CEA), Insulin Growth Factor Binding Protein 2 (IGFBP-2), and Cyclin D1. The immunogenic peptides can be used in cancer vaccines.

La présente invention porte sur des peptides de liaison à HLA-DR (CMH de classe II) issus d'antigènes associés au cancer des ovaires/du sein, du récepteur 2 du facteur de croissance épidermique humain (HER-2/neu), d'un antigène carcino-embryonnaire (CEA), de la protéine de liaison au facteur de croissance de l'insuline 2 (IGFBP-2) et de la cycline D1. Les peptides immunogènes peuvent être utilisés dans des vaccins contre le cancer.

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