Hla fusion molecules and uses thereof

Details Hla fusion molecules and uses thereof Hla fusion molecules and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 38/17 (2006.01) A61P 37/00 (2006.01) C07K 14/74 (2006.01) C07K 16/00 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2595462

The present invention provides a fusion molecule comprising a first domain and a second domain, wherein said first domain comprises the HLA-DR alpha 2 domain or a fragment thereof. Said fusion molecule is capable of modulating the T- cell mediated immune response. Furthermore, pharmaceutical compositions comprising said fusion molecules for the treatment of various diseases such as graft versus host disease, autoimmune diseases, allergic diseases, infectious diseases and tumors in a subject are described.

La présente invention se rapporte à une molécule de fusion comportant un premier domaine et un second domaine, ledit premier domaine comportant le domaine HLA-DR alpha 2 ou un fragment de ce domaine. Ladite molécule de fusion a la capacité de moduler la réponse immunitaire médiée par les lymphocytes T. En outre, l'invention se rapporte à des compositions pharmaceutiques comportant ces molécules de fusion et destinées au traitement chez un sujet de diverses maladies du type réaction du greffon contre l'hôte, maladies auto-immunes, maladies allergiques, maladies infectieuses et tumeurs.

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