Hla-g polypeptides and pharmaceutical uses thereof

Details Hla-g polypeptides and pharmaceutical uses thereof Hla-g polypeptides and pharmaceutical uses thereof

C - Chemistry, Metallurgy

07

K

C07K 14/705 (2006.01) A61K 38/16 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01)

Patent

CA 2742521

The present invention relates to novel proteins and pharmaceutical uses thereof. The invention more specifically relates to novel proteins comprising the sequence of an HLA-5 antigen fused to the sequence of a b2 microglobulin. The invention also relates to methods of producing such polypeptides, pharmaceutical compositions comprising the same, as well as their uses for treating various diseases including organ/tissue rejection.

Cette invention concerne de nouveaux polypeptides et leurs utilisations pharmaceutiques et, spécifiquement, de nouvelles protéines de fusion comprenant un domaine dun antigène HLA-G fusionné à une séquence dune microglobuline b2. Linvention concerne également des méthodes de fabrication de telles polypeptides, des compositions renfermant lesdits polypeptides ainsi que leurs utilisations pour le traitement de diverses maladies, y compris le rejet dorganes/tissus.

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