Hla ligand database utilizing predictive algorithms and...

G - Physics – 06 – F

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Details

G06F 17/30 (2006.01) A61K 39/385 (2006.01) A61K 39/39 (2006.01) A61K 47/48 (2006.01) C07K 14/16 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 14/74 (2006.01) C07K 14/78 (2006.01) C12N 9/12 (2006.01) C12N 9/64 (2006.01) G01N 33/50 (2006.01) A61K 9/127 (2006.01)

Patent

CA 2440740

The present invention generally relates to a MHC ligand database populated with MHC ligand sequences, motifs extended motifs, subm otifs, ligands unique to infected cells, tumor specific ligands, as well as a collection of current and future developed MHC lignad sequences developed by alternative methods. Other than the ligand sequences developed by alternative methods (which are in many cases non-standarized), the remaining ligand sequences are obtained in a standardized and minimum-variable dependent manner from soluble HLA molecules constructed according to the methodology described herein. The present invention further includes methodologies incorporating linear and predicitve algorithm searching and comparison utilities.

La présente invention concerne une base de données de ligands de MHC peuplée de séquences de ligands de MHC, de motifs, de motifs étendus, de sous-motifs, de ligands propres à des cellules infectées, des ligands spécifiques de tumeur, ainsi que d'une collection de séquences de ligands de MHC actuelles et futures développées selon d'autres méthodes. Les séquences de ligands restantes, différentes de celles développées selon les autres méthodes (qui sont dans de nombreux cas non-normalisées), sont obtenues de manière normalisée et dépendante d'une variable minimum, à partir de molécules de HLA solubles construites selon la méthodologie décrite ici. La présente invention concerne également des méthodologies comprenant la recherche d'algorithmes linéaires et prédictifs et des équipements de comparaison.

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