C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A61K 35/14 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C12N 5/10 (2006.01) C12N 15/12 (2006.01) C12Q 1/02 (2006.01) G01N 33/50 (2006.01) G01N 33/564 (2006.01) G01N 33/569 (2006.01)
Patent
CA 2321223
The invention relates to the identification of a susceptibility gene for pre- eclampsia and eclampsia and provides methods and diagnostic kits for diagnosing susceptibility to normal pregnancy, pre-eclampsia, eclampsia, intrauterine growth retardation, miscarriage or miscarriage-related infertility. The invention is based on analysing HLA-G or HLA-G linked nucleic acid, or HLA-G protein or HLA-G mRNA or cells or molecules whose concentration changes as a result of HLA-G action. The invention also provides pharmaceutical compositions for and methods of treatment of the above conditions.
L'invention porte sur l'identification d'un gène de susceptibilité aux pré-éclampsies et éclampsies et sur un procédé et une trousse pour diagnostiquer la susceptibilité à une grossesse normale, à la pré-éclampsie, à l'éclampsie, au retard de croissance intra-utérin, aux fausses-couches, ou à la stérilité due aux fausses-couches. L'invention se base sur l'analyse du HLA-G, ou de l'acide nucléique lié au HLA-G, ou de la protéine HLA-G, ou de l'ARNm du HLA-G, ou de cellules ou molécules dont la concentration varie sous l'action du HLA-G. L'invention porte également sur des préparations pharmaceutiques et des méthodes traitant les états précités.
Bermingham John
Jenkins David M.
Mccarthy Tommie V.
O'brien Margaret
Quane Kathleen A.
Gowling Lafleur Henderson Llp
National University Of Ireland Cork
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