Hla-restricted hepatitis b virus ctl epitopes

Details Hla-restricted hepatitis b virus ctl epitopes Hla-restricted hepatitis b virus ctl epitopes

C - Chemistry, Metallurgy

12

Q

C12Q 1/70 (2006.01) A61K 39/29 (2006.01) A61K 39/385 (2006.01) A61K 47/48 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/02 (2006.01) C07K 14/08 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2115839

Cytotoxic T lymphocyte-stimulating peptides induce HLA-restricted responses to hepatitis B virus antigens. The peptides, derived from CTL epitopic regions of both HBV surface and nucleocapsid antigens, are particularly useful in the treatment and prevention of HBV infection, including the treatment of chronically infected HBV carriers. The peptides can be formulated as HBV vaccines and pharmaceutical compositions, such as lipid-containing compositions for enhancing the HLA-restricted CTL responses. The peptides are also useful in diagnostic methods, such as predicting which HBV-infected individuals are prone to developing chronic infection.

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