Hla typing method and cdna probes used therein

Details Hla typing method and cdna probes used therein Hla typing method and cdna probes used therein

C - Chemistry, Metallurgy

07

H

167/39, 195/1.23

C07H 21/04 (2006.01) C07K 14/74 (2006.01) C12N 15/00 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 1205400

Abstract HLA typing based on restriction length poly- morphism is carried out by: digesting an individual's HLA DNA with a restriction endonuclease that produces a polymorphic digestion pattern with HLA DNA; subjec- ting the digest to genomic blotting using a labeled cDNA hybridization probe that is complementary to an HLA DNA sequence involved in the polymorphism; and comparing the resulting genomic blotting pattern with a standard. This technique may be adapted to make paternity or transplant transfusion compatibility determinations or to make disease association corre- lations to diagnose diseases or predict susceptibility to diseases. Locus specific DNA hybridization probes, particularly probes for genes of Class II loci (D and DR loci), for use in the typing procedure are described.

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