Hmg-coa reductase inhibitors

Details Hmg-coa reductase inhibitors Hmg-coa reductase inhibitors

C - Chemistry, Metallurgy

07

D

167/244, 260/357

C07D 309/30 (2006.01) A61K 31/365 (2006.01)

Patent

CA 1291143

TITLE OF THE INVENTION NOVEL HMG-CoA REDUCTASE INHIBITORS ABSTRACT OF THE DISCLOSURE Novel 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors which are useful as antihypercholesterolemic agents and are represented by the following general structural formulae (I) or (II): Image Image (I) (II) wherein: n is 1 to 5 R is hydrogen or (C1-5 alkyl)?-; R1 is hydrogen or methyl; R2 is hydrogen or methyl; and R3 is hydrogen, C1-5 alkyl or C1-5 alkyl substituted with a member of the group consisting of phenyl, dimethylamino, or acetylamino; and the dotted lines at a, b and c represent optional double bonds and pharmaceutically acceptable salts of the compounds (II) in which R3 is hydrogen are disclosed.

515138

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