Hmg-coa reductase inhibitors

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 309/30 (2006.01) A61K 31/19 (2006.01) A61K 31/215 (2006.01) A61K 31/365 (2006.01) A61K 31/44 (2006.01) C07C 59/56 (2006.01) C07C 69/732 (2006.01) C07D 405/08 (2006.01) C07D 407/08 (2006.01)

Patent

CA 2046584

2046584 9010444 PCTABS00002 Disclosed are novel 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors useful as antihypercholesterolemic agents represented by formula (I), and the corresponding ring-opened hydroxy acids and esters derived therefrom and pharmaceutically acceptable salts thereof. Pharmaceutical compositions containing said compounds and method of inhibiting the biosynthesis of cholesterol therewith are also disclosed.

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