Hmg-coa reductase inhibitors

Details Hmg-coa reductase inhibitors Hmg-coa reductase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 309/30 (2006.01) A61K 31/215 (2006.01) A61K 31/365 (2006.01) C07C 43/196 (2006.01) C07C 47/37 (2006.01) C07C 69/732 (2006.01) C07C 69/757 (2006.01) C07C 317/46 (2006.01) C07D 307/92 (2006.01) C07F 7/18 (2006.01)

Patent

CA 2078888

2078888 9115482 PCTABS00007 Compounds of either general formulae (I) and (II), wherein R1 represents C1-8 alkyl, C3-8 cycloalkyl, C3-8 cycloalkyl(C1-8)alkyl, C2-8 alkenyl, or C1-6 alkyl substituted phenyl group; R3 represents a hydrogen atom or a substituent R4 or M; R4 represents a C1-5 alkyl group, or a C1-5 alkyl group substituted with a group chosen from substituted phenyl, dimethylamino, or acetylamino; R5 represents a hydrogen atom or C1-3 alkyl group; M represents a cation capable of forming a pharmaceutically acceptable salt; Q represents C=O or CHOH; and each of a and b is independently a single or double bond are potent inhibitors of the enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and, therefore, are useful in the treatment or prevention of hypercholesterolaemia, hyperlipoproteinaemia and atherosclerosis.

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